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1.
Article | IMSEAR | ID: sea-218463

ABSTRACT

Introduction: Salivary gland tumors account for about 3% of head and neck tumors and the majority are benign in nature. Among these, the most common pathological type is pleomorphic adenoma also called the mixed tumor. It is a kind of tumor containing glandular tissue, myxoid and cartilage-like tissue. As the structure of the tissue is diverse, it is called a “mixed tumor.” Actinomycosis is a chronic suppurative bacterial infection caused by Actinomyces israelii. In this case report, we are presenting a rare co-existence of pleomorphic adenoma and Actinomycosis in the infratemporal fossa. Case description: A 40-year-old female patient complains of pain over the upper left back tooth region for the past 6months. The patient had a past history of a small lesion in 28 region which resulted in constant irritation. The patient had consulted the dentist for the same and underwent extraction of 28 and 38 three years back, which was thought to be the cause of the swell- ing. Conclusion: The case highlights the importance of proper history taking, clinical examination, and histopathological examina- tion in arriving at a precise diagnosis of a lesion irrespective of size and clinical presentation.

2.
J Cancer Res Ther ; 2020 Jul; 16(3): 546-550
Article | IMSEAR | ID: sea-213857

ABSTRACT

Background: The objective of this study was to evaluate the serum and salivary L-fucose in oral potentially malignant disorders (OPMDs) and oral cancer (OC) in order to investigate the possibility of using this as biomarker for early diagnosis. Materials and Methods: The study included 85 participants, who were grouped as control (30), OPMDs patients (25), and OC patients (30). Serum and unstimulated whole saliva were collected from participants of all groups and fucose estimation was done using spectrophotometry. The results were tabulated and analyzed statistically. Results: The mean serum L-fucose levels in normal, OPMDs, and OC group were 3.49, 19.18, and 35.75 mg/dl, respectively, while the levels of salivary L-fucose were 3.18, 7.02, and 11.66 mg/dl, respectively. A highly significant rise (P < 0.001) in serum and salivary L-fucose was observed in the study participants compared to control. Conclusions: The present study showed a significant and gradual increase in serum and salivary L-fucose from control to OPMDs to OC. From this study, we suggest that L-fucose can be used as a reliable biomarker and saliva can be used as a diagnostic fluid for screening and early detection of OC

3.
Article | IMSEAR | ID: sea-192048

ABSTRACT

Verrucous carcinoma (VC) should be considered a distinct clinicopathologic entity different from the more common oral squamous cell carcinoma (OSCC) because of its unique biological behavior. Best way to understand the behavior of these carcinomas is to study them by means of molecular methods, especially in tumor progression tests and Bcl-X is an important antiapoptotic member of the Bcl-2 family and is one of the newest and most useful markers to determine the aggressiveness of many carcinomas. The relationship between this Bcl-X protein and carcinomatous behavior toward it is not studied extensively, which we attempted to evaluate using immunohistochemical analysis in selected carcinomas of the head and neck region. Method: We studied Bcl-X protein expression in sections of thirty OSCC and ten VC samples and correlated this with tumor differentiation. Results: There was a significant difference in cytoplasmic staining of Bcl-X expression with statistical analysis (P < 0.005) for VC and OSCC when compared as a group. No significance was seen among the different histological grades of OSCC and when compared with VC individually. Conclusion: The significant result between OSCC and VC suggests that their biologic course is comparable and can be helpful in differentiating them with each other for establishment of a better treatment protocol.

4.
Article in English | IMSEAR | ID: sea-163460

ABSTRACT

Medicinal and aromatic plants are gift of nature and are being used against various infections and diseases in the world since ages. Species of the genus Bridelia stipularis var scandens is reported to be used traditionally for treating various oral diseases. However, the antimicrobial effect of these plant materials against oral pathogens is not proved. Therefore, we have done the present study. Aim is to find out the anticandidal effect of water extract of Bridelia stipularis against four common oral candidal pathogens. The leaves after identification and authentication by a botanist were collected, air dried, pulverized to fine powder using household blender. The water extract was prepared using cold percolation method. The standard Candida species, Candida albicans, Candida parapsilosis, Candida glabrata and Candida tropicalis obtained from Post Graduate Institute (PGI), Chandigarh was procured. Antifungal activity was determined by Kirby Bauer well diffusion method and Time kill assay. All four species of Candida showed variable results with diameter of zone of inhibition ranging from 12mm to 21mm on Sabouraud’s dextrose agar with both 6 hour and 24 hour peptone water subculture. Time kill assay showed inconsistent results even after 24 hours of exposure with the crude extract of Bridelia stipularis. All four species of Candida causing oral infections are moderately sensitive to crude water extract of dried leaves of Bridelia stipularis.


Subject(s)
Antifungal Agents/pharmacology , Antifungal Agents/therapeutic use , Candida/drug effects , Candida/pathogenicity , Euphorbiaceae/pharmacology , Euphorbiaceae/therapeutic use , Phytotherapy , Plant Extracts/pharmacology , Plant Extracts/therapeutic use , Plant Leaves/pharmacology , Plant Leaves/therapeutic use
5.
Article in English | IMSEAR | ID: sea-163605

ABSTRACT

A comprehensive study on the phytochemical contents and antioxidant activities of alcoholic extracts of five plant materials, such as mango leaves, fibrous pericarp of coconut and areca nut, tender twigs of Jatropha curcus and Jatropha gossipifolia, used for oral health and diseases by people of Dakshina Kannada district, Karnataka, India was conducted. The extract of different plant materials contained various levels of phenolics, flavonoids, saponins, tannins and so on. Various biochemical assays performed to assess the radical scavenging activity have shown good activity and was found to be concentration dependent. Of five selected materials, mango leaves, fibrous pericarp of coconut and areca nut showed more antioxidant activities than tender twigs of J.curcus and J. gossipifolia.

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